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If weight drops, it's often because training and nutrition consistency improved—not because the peptide guarantees fat loss

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In a randomised, double-blind study that included 38 diabetic patients, metformin increased silent information regulator sirtuin 1 (SIRT1) gene expression, SIRT1 chromatin promoter accessibility, SIRT1 protein synthesis, and decreased p70S6K phosphorylation while having a positive effect on plasma N-glycans [119]