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For randomised clinical trials, the Jadad scale (Jadad et al., 1996), as used to assign a quality score ranging from 0 to 5, based on randomisation, blinding, and withdrawal reporting

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Kisspeptin-13 stimulates the HPA axis by interaction with α2 receptors where intracerebroventricular administration induces hyperthermia and causes anxiety-like behavior in rats, while interaction with 5-HT2 receptors causes antidepressant-like effects in mice [245,246]