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doi: 10.1186/s10194-021-01369-6 206

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Most drug metabolisms are closely associated with the cytochrome P450 enzymes, so the drugs, particularly those ones metabolized through the cytochrome P450 system, can increase hepatic heme turnover ( Figure 1V ) and affect the ALAS1 through the negative feedback regulation loop, thus leading to the excess production of heme precursors

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