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For research purposes, the practical use cases are: GLP-1 plateau rescue — adding cagrilintide to a stalled semaglutide or tirzepatide protocol GLP-1 dose reduction — using cagrilintide to maintain weight loss while tapering GLP-1 Standalone titration — cagrilintide at 2.4 mg/week produced ~8-10% weight loss in monotherapy trials But here's the synthesis problem: cagrilintide has the same lipid-conjugation chemistry as semaglutide