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59 C/EBP homologous protein (CHOP) plays an important role in ERS-induced apoptosis, which is mainly regulated by three sensors in the inner membrane of the endoplasmic reticulum, namely, protein kinase RNA-like endoplasmic reticulum kinase (PERK), activating transcription factor 6 (ATF6), and inositol needs protein 1 (IRE1)
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