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Semaglutide produced less weight loss than tirzepatide head-to-head, about 14% versus 20%.² Its body-composition substudy measured a roughly 62:38 fat-to-lean loss split by mass, compared with about 75:25 for tirzepatide in a separate trial.⁵ The scan overstates muscle loss because lean mass includes water and organ tissue

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Association between lean body mass and osteoarthritis: a cross-sectional study from the NHANES 2007–2018