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Crocetin is a naturally occurring dicarboxylic acid apocarotenoid that exhibits a chemopreventive effect on glioblastoma cells by inhibiting proliferation and inducing morphology changes that is mainly mediated through activation of neuronal markers (class III β-tubulin and neurofilament) and suppression of mesenchymal markers (cluster of differentiation 44/90, octamer-binding transcription factor 3/4, and C-X-C chemokine receptor type 4) in glioma cells