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Resveratrol synergized with TMZ to activate AMP-activated protein kinase (AMPK), which in turn suppressed mTOR signaling and downregulated anti-apoptotic proteins like B-cell lymphoma 2 (Bcl-2), amplifying TMZ-induced cytotoxicity [71]

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hybrid architecture of support vector machines and GNN) to project multi-dimensional omics signatures onto clinical phenotype spaces, yielding actionable therapeutic inferences