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this process is exacerbated under glucose deprivation conditions due to AMPK-mediated fatty acid oxidation (FAO) pathway activation, forming a positive feedback loop of lipid peroxidation substrate accumulation (Kshattry et al., 2019

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For example, yeast with mutated sod1 accumulate DNA mutations, 35 and SOD1 knockout mice develop hepatocellular carcinoma, presumably as a result of oxidative damage of hepatocytes