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Reported advantages of intranasal delivery include: Bypass of hepatic metabolism , preserving more of the active compound Faster onset compared to oral capsules, often within minutes Convenience — no needles, no refrigerated injectables for many formulations Potential nose-to-brain pathway via the olfactory and trigeminal nerves for certain molecules That said, absorption through the nasal route varies dramatically based on formulation
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DoD periodically updates the panel – for example, fentanyl was added in 2019 , and Delta-8 THC (a hemp-derived variant) was added around 2021 once it became popular
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