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Because GHK-Cu’s value comes from sustained, systemic support rather than a one-time concentrated dose, the format that’s easiest to use consistently — without needles, mixing, or refrigeration — is generally the more effective choice in practice

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Consistent with prior structural studies of AMPARs 48,49,50,51,53 , the M3 helix linkers in the B/D position also undergo an outward motion (Fig