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Unlike some lipid-based or nanocarrier formulations that may pose toxicity concerns, cyclodextrins generally have low immunogenicity and toxicity, making them a preferred choice for improving drug solubility and stability (Nicolaescu et al., 2025)

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Studies have indicated that heroin reduces mitochondrial potential and alters the Bcl-2/Bax ratio, thereby affecting cell survival (Solis et al., 2017)