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Le principe fondateur repose sur l'hypothèse formulée par Wallis et Heap (1968) puis affinée par Ng et Borstein (1993) : les différentes activités biologiques de la hGH sont portées par des domaines protéiques distincts

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Under normal conditions the intestinal epithelium has numerous adaptations such as anti-microbial peptides and mucins that keep the intestinal microbiota away from the gut epithelial layer [107–110]