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During an outbreak of pellagra in Mozambican refugees, for example, French researchers measured 4‑pyridone and 6-pyridone as well as N'‑methylnicotinamide in 24h urine collections (Dillon et al., 1992)
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Current laboratory investigations further evaluate intracellular signaling involving TGF-β , MAPK/ERK , PI3K/Akt , NF-κB , matrix metalloproteinases (MMPs) , tissue inhibitors of metalloproteinases (TIMPs) , copper-dependent enzymes, and additional molecular pathways associated with extracellular matrix regulation and cellular remodeling
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