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Therefore, while the data we have summarized from human data and murine models of e-cigarette exposure demonstrate that e-cigarette use alters inflammation, immune phenotype, and microbiome composition upper and lower airways (Figure 8), subsequent studies are needed to validate whether these changes are associated with disease

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Advise patients not to drive or operate heavy machinery until the effects of concomitant use of the benzodiazepine or other CNS depressant have been determined