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A 2010 study also found kidney function declined much quicker in one form of kidney disease in those who supplemented B12 compared to no supplementation.[2] It is difficult to 100% confirm all forms used in these studies were cyanocobalamin, but the ones that did mention the type of B12, did use cyanocobalamin and this is often the most commonly supplemented form

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This interaction allows the transcription factor to translocate to the cell nucleus and allows the genes present in the ARE domain to be expressed