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10 , 11 , 12 , 13 , 14 Notably, there is a growing recognition of systematic regulation beyond the central nervous system (CNS), with a large number of clinical and preclinical studies having shown that gut microbiota dynamically interact with the CNS through the gut-brain axis and their dysbiosis is closely related to the onset and progression of NDs

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(2002), “Free radical-induced damage to DNA : mechanisms and measurement”, Free radical biology & medicine , Vol

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