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Animals and Ethic Statement The experiments reported in this study followed the ethical guidelines for investigations of experimental animals approved by the Animal Care and Use board and the Ethical Committee of Spanish Council of Scientific Research (Animal Care Unit Committee IPBLN-CSIC # protocol 202-11-3), and they were performed in accordance with the guidelines from Directive 2010/63/EU of the European Parliament on the protection of animals used for scientific purposes and for investigations of experimental pain in conscious animals