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The FDA indication for semaglutide 2.4 mg to reduce the risk of cardiovascular death, non-fatal myocardial infarction or non-fatal stroke in adults with established cardiovascular disease and overweight or obesity represents a major regulatory milestone ( Mechanistically, SELECT strengthens the argument that GLP-1 RA cardiovascular benefit is not simply a consequence of improved glycaemia ( 4.2 Chronic kidney disease and cardiorenal protection FLOW was the first dedicated kidney outcomes trial of a GLP-1 RA and demonstrated that semaglutide reduced a composite kidney endpoint in patients with T2DM and chronic kidney disease ( Figure 2D

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