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*GHK-Cu figure represents collagen density increase (subdermal echogenicity), not surface wrinkle depth

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Regarding diabetic nephropathy, results of studies on diabetic rats showed that ALA exerts a strong protective effect on diabetic kidneys [65] and that oral ALA supplementation is able to prevent early development and progression of diabetic nephropathy acting as an anti-hyperglycemic, antioxidant, anti-inflammatory, anti-fibrotic and anti-apoptotic compound [66]