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Extended phase: weeks four through eight By weeks four through eight, substantial healing progress is often evident for responding individuals

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This study establishes a step-wise mechanism of circulating tumour cell attachment to the endothelium and extravasation, whereby, during early arrest, weaker adhesion is mediated by CD44 and αvβ3 integrin, and adhesion strengthening and stabilization is mediated by α5β1 integrin adhesion to luminally deposited fibronectin on endothelial cells