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Exemplary second agents and treatments include, for example, anticancer agents are a chemotherapeutic agent, radiation therapy, an antibody, a peptide, a gene therapy vector, a virus, such as an oncolytic virus, and a nucleic acids, such as gene therapy vectors that deliver an anti-cancer protein or other therapeutic protein

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In human cells, PGRMC1 deletion reduces CYP51A1 enzymatic activity, thereby suppressing cholesterol biosynthesis and promoting the accumulation of toxic sterol intermediates