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In response to SASP, macrophages are recruited into the articular space and secrete proinflammatory factors to activate synovial fibroblasts, which promote osteophyte formation and further exacerbating osteoarthritis [140]

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HRW can be obtained in several ways, including electrolysis of water, bubbling H 2 into water, and mixing metallic non-ionic magnesium (Mg) or its hydride form (MgH 2 ) with water [27,33]