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A novel high-efficiency transdermal patches for combinational therapy of Alzheimer's disease: Donepezil/vitamin B12-loaded nanofibers - ScienceDirect

In the chronic inflammatory state, TNF-α shifts the predominant cytokine environment towards pro-inflammatory cytokines, such as IL-1, IL-6, IL-17, IL-22, and interferon gamma (IFN-γ), while simultaneously reducing the secretion of anti-inflammatory cytokines, in particular IL-4 and IL-10 [12,13]

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Fibrosis is part of the injury, and progesterone receptors are present not only in glands and stroma but also in smooth muscle cells and fibrotic tissue adjacent the DIE lesions [56]