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Moreover, neutrophil extracellular traps (NETs) are regarded as a source of autoantigens that contribute to chronic inflammation and autoimmune disorders in the absence of DNAse and ALP-mediated degradation of cytotoxic phosphorylated NET-bound cell-free DNA and granule proteins [55,56]

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PDKs are activated by NADH and acetyl-CoA and inhibited by pyruvate, ADP, CoASH, Ca 2+ and Mg 2+