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Mechanistically, ARA-290 is all about modulating the injury-response environment : dampening excessive inflammation, reducing neuropathic pain signaling, and promoting nerve repair and microvascular protection

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Hormone and Metabolic Modulators added to the Prohibited List, including elacestrant (added as an anti-estrogen), S519 and S597 (examples of insulin-mimetics), and MOTSc (an example of an AMP-activated protein kinase activator)