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A phase I clinical trial is studying the safety and preliminary efficacy of telisotuzumab–vedotin in patients with advanced solid tumors (NCT02099058)

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PKA phosphorylates numerous substrates, while EPACs act as GEFs catalyzing the conversion of the small GTPases Rap1 and Rap2 from an inactive (GDP-bound) to an active form [guanine triphosphate (GTP)-bound] (16)