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Santos and colleagues showed that human GBP1 can bind LPS on cytosolic bacteria and assemble a platform that promotes caspase-4 recruitment and activation, providing a mechanistic bridge between IFN-induced cell-autonomous immunity and noncanonical inflammasome triggering
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Unlike prior studies solely addressing ferroptosis or nanotechnology in tumor therapy, this work first systematically outlines the synergistic potential of nanoparticles in combined ferroptosis–immunotherapy strategies
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