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Severe Dermatological Toxicity Severe hand–foot syndrome occurred in 3 (42.9%) DPYD ∗2A carriers treated with a standard fluoropyrimidine dose and 242 (43.2%) wild-type patients treated with a standard dose in the study by Deenen et al 61 (RR 0.99, 95% CI 0.25–1.82)

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The design logic was to capture growth hormone's lipolytic effect while deliberately leaving behind the growth-promoting and anabolic portions of the full hormone