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If interaction across populations and treatments was significant, the means were separated using Tukey’s test using the “ multcompview ” and “ lsmeans ” packages at α = 0.05

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Methods: Patients with cirrhosis were screened on transthoracic echocardiography (TTE) with tissue Doppler imaging for presence of LVDD, and those with ischemic heart disease, pacemaker in situ or known arrhythmia, prior use of beta blocker, valvular heart disease, anemia, uncorrected thyroid dysfunction, and hepatocellular carcinoma were excluded