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Thus, H 1 -receptor agonists and H 3 -receptor antagonists are both in development as anti-obesity therapeutics, although more attention has been focused on the development of H 3 -receptor antagonists, since they are expressed almost exclusively in the central nervous system and their modulation will have fewer peripheral adverse effects

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Hormonal Changes That Drive Regain Weight loss triggers persistent changes in hormones that regulate hunger and fullness: Leptin decreases dramatically