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For example, in systemic juvenile idiopathic arthritis (sJIA), a disease with high MAS propensity, soluble SR-I1 correlates with MAS activity and TRIM8 upregulation in monocytes/macrophages augmenting IFN- γ responsiveness, providing a molecular mechanism for macrophage hyperactivation (70, 71)

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2, 1407–1413, 10.1007/s40200-020-00661-7