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Generally, the existing data clearly demonstrate that direct Hg-SH interaction induces oxidative stress through inhibition of SOD, TrxR, and SelW activity, as well as decreasing Trx and GSH levels and availability (Fig
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HDR UK is funded by UK Research and Innovation, the Medical Research Council, the British Heart Foundation, Cancer Research UK, the National Institute for Health and Care Research, the Economic and Social Research Council, the Engineering and Physical Sciences Research Council, Health and Care Research Wales, Health and Social Care Research and Development Division (Public Health Agency, Northern Ireland), Chief Scientist Office of the Scottish Government Health and Social Care Directorate
